Martin P. Paulus

The senior author of the roadmap and, more importantly for the wiki, the source of the sentence its interoceptive-psychopathology page is built around. Paulus & Stein (2010), “Interoception in anxiety and depression,” proposed that mood and anxiety disorders arise from failures to appropriately anticipate changes in interoceptive states — and it is Paulus & Stein that the roadmap cites (ref 97) when it describes the pathological case as interoceptive input decoupling from prediction, presenting as “noisy afferent interoceptive inputs.” His framework is the clinical hinge between the predictive-coding theory the wiki tracks through Seth and Barrett and the actual disorders.

Anticipation as the locus of dysfunction

Paulus’s distinctive move is to locate psychopathology not in interoceptive sensing but in interoceptive prediction — the anticipatory limb. On this view an anxious brain is not one that feels its body too much or too little but one whose forecasts of upcoming bodily states are miscalibrated, so that ordinary fluctuations generate outsized prediction error. This is why he sits naturally at the head of a document trying to marry hierarchical Bayesian models to clinical categories: his 2010 claim is that clause of the computational theory, stated before the formal apparatus was imported.

Reach across disorders

His empirical programme spans the transdiagnostic list the roadmap assembles: interoceptive dysfunction in drug addiction (with Naqvi and Bechara, on the insula’s role in urges and decision-making), in anorexia nervosa (with Khalsa and Feusner, on altered caloric-anticipation interoception), and in anxiety and depression. That breadth is why interoceptive dysfunction reads as a dimension cutting across diagnoses rather than a feature of one.

Placement

The clinical-theoretical anchor of the LIBR cluster (sahib-khalsa, Feinstein) and the person whose 2010 thesis the roadmap’s psychopathology section elaborates. His disclosures on the roadmap are substantial (Warren Foundation and multiple NIH/NIDA grants; a LIBR affiliation and UpToDate royalties) — worth recording plainly, alongside the note that the roadmap is a Warren-funded, LIBR-organized document on which he is senior author.